How Many Puffs of Vape is Equal to 1 Cigarette? Ecigator Vaping & e Cigarettes Cypress Fairbanks Independent School District E Cigarettes, Vapes, and other Electronic Nicotine Delivery Systems (ENDS) FDA Vaping isn't just a "safer" alternative; it comes with hidden costs to your health. A single disposable vape can have up to 5,000 puffsthe equivalent of 25 packs of cigarettes. Beyond the E cigarettes and Vaping Commercial Tobacco Use MN Dept. of Health