The most pregnancy friendly lubricants are the water based kinds. These lubes are water soluble, which means they dissolve in water. They're safer for you and your baby, typically because they contain fewer chemicals than Pre Seed Fertility Lubricant For Use By Couples Trying To Conceive Each safeway Conceive Plus Fertility Lubricant, Fertility Personal Lubricant Formula for Couples Trying to Conceive, Multi Use Tube 2.5 fl.oz. HSA FSA Eligible Walmart.com PreSeed is the first sperm friendly vaginal lubricant recommended for women who are trying to conceive but experience vaginal dryness during sexual intercourse. Most other lubricants either kill sperm or alter the morphology motility Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your