Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Myth or Fact Saliva is the best lubricant to use when trying to conceive MYTH Saliva can actually hinder the sperms journey to the egg and is not recommended as a natural lubricant while TTC. Fertility Lubricant for Conception Support Sperm Safe Lube Bird&Be Amazon.com: Pre Seed Fertility Lubricant, For Use by Couples Trying to Conceive : Health & Household Is Your Lube Toxic to Your Fertility: Find a Reproductively Friendly Option Dr Lora Shahine